Синтез и антиметастатическая активность металлокомплексов на основе замещенных амидов пиридинкарбоновых кислот и тетрахлорида платины

Previously unreported platinum tetrachloride derivatives have been synthesized via the interaction between dipotassium- and disodiumhexachloroplatinates with substituted amides of nicotinic and isonicotinic acid. The synthesized compounds exhibit low general toxicity and show high antimetastatic activity with respect to experimental melanoma B-16 and Lewis lung carcinoma strains.