A kind of inclusion compound of Sorafenib and beta cyclodextrin and preparation method thereof

The invention discloses a kind of inclusion compound of Sorafenib and beta cyclodextrin and preparation method thereof inclusion compound to contain Sorafenib molecule and beta cyclodextrin molecule, and Inclusion ratio, i.e. mol ratio are 1：0.8~1.5；The defects of Sorafenib beta cyclodextrin clathrate provided by the present invention and preparation method thereof overcomes current Sorafenib preparation production technology to a certain extent, obtained inclusion compound is the solid forms dramatically different with known Sorafenib Tosylate crystal formation, can effectively avoid Sorafenib Tosylate polycrystalline present in preparation process or mixed crystal phenomenon.Preparation method is easy to implement, and material loss is small, mild condition, suitable for industrial production.