MP516 KDIGO-RECOMMENDED PTH LEVEL ACCELERATES AORTIC CALCIFICATION IN PATIENTS NEW TO HEMODIALYSIS

Results: Aortic arch calcification was observed 46% of patients at baseline and increased to 80% during the three-year study period. In addition, forty-eight of the 102 patients achieved the outcome. The mean daily dose of calcium carbonate (1,000-mg units) for three years (odds ratio: 2.2 [95% CI 1.5 - 3.4]), an iPTH level of 180 pg/ml or above (3.9 [1.6 - 10.6]), and age (1.5 [1.0 - 2.3]) were significantly associated with progression of aortic calcification. On the other hand, the presence of diabetes, use of activated vitamin D and statin, mean levels of serum calcium and phosphate and factors related to lipid for three years were not associated with the progression of aortic calcification. Conclusions: The KDIGO's guideline recommend PTH level is maintained in the range of two to nine times the upper normal limit in patients with CKD stage5D, regarding the relative risk of death. However, in view of vascular calcification, it is important to control the PTH levels more strictly from the early stage of dialysis initiation, in addition to reducing the doses of calcium-containing phosphate binders as far as possible.