Evaluation of pharmacotherapy in inpatients with mania in bipolar disorder.

Background The studies concerning prophylactic treatment in bipolar disorder suggest it should be introduced after the first manic episode [1]. Also early polytherapy is promoted, mainly mood stabilizers and antipsychotics. Antipsychotics are recommended in short-term use [2], but they are also used after improvement. Typical antipsychotics are effective in monotherapy in 70% of patients, like mood stabilizers.[3] The combination of antipsychotics and mood stabilizers is superior to monotherapy in rapid control of agitation.