Transforming Growth Factor‐Beta and bcl‐2 Distribution Patterns Distinguish Trichoepithelioma from Basal Cell Carcinoma

background Trichoepithelioma (TE) and basal cell carcinoma (BCC) have many features in common both clinically and histologically. Despite these many similarities TE and BCC represent different biological entities. objective Recently, bcl-2 and CD34 have been reported as reliable markers in distinguishing the two types of tuntor. Transforming growth factor-beta (TGF-β), a multifunctional regulator of both cell growth and differentiation, was evaluated in this study. methods The immunohistochemical expression of TGF-β was compared with the distribution patterns of bcl-2 and CD34 in five BCCs, five TEs, and seven borderline cases. results All five TEs showed a diffuse cytoplasmic staining of tumor cells for TGF-β. whereas four of five BCCs were TGF-β negative. Of the seven equivocal cases of TE/BCC, five tumors demonstrated TGF-β positivity in combination with negative bcl-2 staining corresponding to TE. The remaining two cases demonstrated the opposite staining pattern, characteristic for BCC. conclusion The TGF-β staining pattern appears to be a helpful additional marker together with bcl-2 in differentiating between TE and BCC. The demonstrated staining differences may relate to the distinct origin and biological behavior of the two tumors and may therefore be of value in subsequent patient management.