Doxapram in the treatment of idiopathic apnea of prematurity: desirable dosage and serum concentrations

Since the introduction of aminophylline for the treatment of idiopathic apnea of prematurity, successful treatment has been documented, j,2 but more aggressive measures such as continuous positive airway pressure or mechanical ventilation may be required. Doxapram, an analeptic agent with a wide safety margin, is an effective respiratory stimulant in adults, 3 and has been used to overcome idiopathic apnea of prematurity. 4 Recently, the efficacy and safety of doxapram in premature neonates with severe idiopathic apnea resistant to treatment with aminophylline have been documented? 4 Our purpose was to determine the appropriate dosage of doxapram by measuring its serum concentrations.