Clinical observation on azasetron in different juncture injection for preventing postoperative nausea and vomiting

AIM:To evaluate the prophylactic effect of azasetron in different juncture injection on postoperative nausea and vomiting(PONV)during patients controlled intravenous ananlgesia(PCIA).METHODS:One hundred and twenty patients,scheduled for selective abdominal operations,were randomly divided into four groups:patients received an preoperative intravenous injection of 10 mg azasetron(Group A,n=30),patients received an intravenous injection of 10 mg azasetron during abdominal cavity(Group B,n=30),patients received an intravenous injection of 10 mg azasetron when the operation were finished(Group C,n=30),patients with no azasetron as control(Group D,n=30).The incidence rate and score of PONV,the visual analogue scales(VAS)and Ramsay scores were recorded at 4,8,12,24,48 h postoperatively.RESULTS:There was significant difference between the postoperative VAS during 12 to 48 h and that of 4 h postoperatively(Ρ0.01 or Ρ0.05).There was no somnolence and deep calm happening.The incidence of PONV in Group A was significantly lower than that in Group D(Ρ0.01 or Ρ0.05).The incidences of PONV in Group C in postoperative 0 to 4 h and 4 to 24 h were significantly lower than that in Group D(Ρ0.05).There was no significant difference between Group B and D(Ρ0.05).CONCLUSION:A preoperative intravenous injection of 10 mg azasetron can be used effectively to prevent PONV during PCIA.