Polymorphism of genes of the renin-angiotensin system ACE, ATIR, and AT2R in patients with pulmonary tuberculosis

The investigation was aimed at testing the hypothesis on the possible role of some genes of the renin-angiotensin system in the formation of innate immunity to tuberculosis. It is known that insertion-deletion (I/D) polymorphism of the gene encoding the angiotensin-converting enzyme (ACE) influences the concentration of angiotensin II in the human organism and, indirectly, many stages of metabolism. On one hand, homozygotes of deletion in the ACE gene (DD genotype) are characterized with obesity, arterial hypertension, hypocholesterolemia, and some other pathological conditions. On the other hand, it was demonstrated that hypercholesterolemia is common pathology for patients with pulmonary tuberculosis (C. Perez-Guzman et al., 2005).