Deregulated expression of cryptochrome genes in human colorectal cancer

Gianluigi Mazzoccoli,Tommaso Colangelo,Anna Panza,Rosa Rubino,Angelo De Cata,Cristiana Tiberio,Maria Rosa Valvano,Valerio Pazienza,Giuseppe Merla,Bartolomeo Augello,Domenico Trombetta,Clelia Tiziana Storlazzi,Gemma Macchia,Annamaria Gentile,Francesca Tavano,Manlio Vinciguerra,Giovanni Bisceglia,Valeria Rosato,Vittorio Colantuoni,Lina Sabatino,Ada Piepoli

Deregulated expression of cryptochrome genes in human colorectal cancer

2016

Background Circadian disruption and deranged molecular clockworks are involved in carcinogenesis. The cryptochrome genes (CRY1 and CRY2) encode circadian proteins important for the functioning of biological oscillators. Their expression in human colorectal cancer (CRC) and in colon cancer cell lines has not been evaluated so far.

Keywords:

Cancer research
Cryptochrome
Molecular medicine
ENCODE
Biology
Colorectal cancer
Carcinogenesis
CLOCK
Circadian rhythm
Gene
Cancer
Gene expression
Survival rate
Cell cycle
Ectopic expression

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