Late Breaking Abstract - The role of High Flow Nasal Cannula in reducing hypoxemic events during bronchoscopic procedures compared to Low Flow Nasal Cannula: a metanalysis

High Flow Nasal Cannula oxygenation method is effective in oxygenation of patients with respiratory failure and has shown clinical benefits over Low Flow Nasal Cannula. We performed a metanalysis to evaluate the potential favorable impact of the High Flow Nasal Cannula oxygenation during bronchoscopy and related procedures like EBUS-TBNA. Eight studies with 488 patients have been included in this metanalysis, after screening a bulk of 144 studies. All these studies met quality criteria as defined by ROB-2 tool l to evaluate the risk of bias in the included randomized controlled studies and ROBINS-I tool for non-randomized studies. Patients that underwent bronchoscopy (EBUS and/or Fiberoptic bronchoscopy) with the use of High Flow Nasal Cannula experienced less hypoxemic events/desaturations compared to patients under Low Flow Nasal Cannula treatment (O.R.= 0.24; 95% CI= 0.16,0.37; p Desaturation events were lower using HFNC whether FOB +/-BAL or Biopsy was performed (O.R.=0.36; 95% CI= 0.2,0.65; p<0.01; I2 = 83%) or EBUS-TBNA (O.R.=0.15; 95% CI= 0.08,0.30; p<0.01; I2 = 0%). This abstract shows that that High Flow Nasal Cannula oxygen therapy might more effective compared to Low Flow Nasal Cannula therapy in reducing hypoxemic events during bronchoscopy, especially during EBUS-TBNA.