AB0790 Frequency of osteoporosis in postmenopausal women with systemic sclerosis

Background The prevalence of low bone mass or osteoporosis in patients with systemic sclerosis (SSc) varies significantly between studies performed in different countries and vary from 3% to 51% (Omair MA et al. 2013). Objectives To determine the frequency of osteoporosis (OP) in postmenopausal women with SSc in comparison with healthy control. Methods 163 postmenopausal women were enrolled in the study: 83 with SSc (mean age 58.5±8.1 years, mean disease duration 9.7±6.8 years) and 80 healthy control (mean age 59.2±6.6 years). Demographic characteristics and risk factors for OP in study groups are summarised in table 1. BMD was measured at lumbar spine, femoral neck and total hip by dual energy X-ray absorptiometry (DXA, Hologic 4500A). BMD decreasing grade was determined in according to WHO criteria. Results BMD in women with SSc was significantly lower than in control group at any site: lumbar spine – 0.832±0119 vs 0.867±0,098 g/sm2 (p=0.031); femoral neck – 0.633±0.098 vs 0.739±0.114 g/sm2 (p OP was significantly more often in SSc patients taking oral glucocorticoids compared to those without glucocorticoid therapy (39% and 20%, respectively, p Conclusions OP in postmenopausal women with SSc were detected among 1/3 of cases, significantly exceeded its frequency in healthy control. Risk factors for OP were age, oral glucocorticoids and interstitial lung disease. Reference [1] Omair MA, Pagnoux C, McDonald-Blumer H, Johnson SR. Low bone density in systemic sclerosis. A systematic review. J Rheumatol.2013;40(11):1881–90. doi:10.3899/jrheum.130032 Disclosure of Interest None declared