Immunoglobulin levels in malaria infected Nigerians with and without abnormal haemoglobin.

: Comparative studies were made between malarial parasitaemia in Nigerians with and without abnormal haemoglobins. The three main classes of immunoglobulins (i.e. IgG, A and M) were assayed in these groups of patients and the mean values were compared. Those with abnormal haemoglobins S or C (HbS or HbC) were compared with those with normal control haemoglobin A (HbA). HbSS malarial patients have the highest mean values of the 3 classes of immunoglobulins. This is followed by HbAS patients while patients with normal Hb have lowest mean values for IgG and IgM. The significance of the results is discussed.