1. Clinical Efficacy of Proctosedyl Suppositories on Internal Hemorrohoides
1976
The clinical efficacy of Proctosedyl suppositories, a form of conservative therapy for acute hemorrhoidal attacks, was evaluated by the single-blind method with placebo. A total of 60 patients (Proctosedyl: 30 cases, 14 males, 16 females ; placebo: 30 cases, 21 males, 9 females), mainly afflicted with internal hemorrhoids, participated. Progress was observed over a period of 2 weeks. Efficacy was assessed by determination of the point decrease ratio, based on the judgement standards of Tab. 5. The clinical efficacy of Proctosedyl was evaluated to be remarkable in 6 cases (20.0%), effective in 17 cases (56.7%), ineffective in 7 cases (23.3%); placebo was remarkably effective in 0 cases (0%), effective in 4 cases (13.3%) and ineffective in 26 cases (86.7%). Proctosedyl ameliorated pain (spontaneous and defecation), hemorrhage, and swelling, both subjetive and objective symptoms, although hemorrhoidal size was not reduced. The only side effects were the feeling of a foreign body inside the anus (Proctosedyl) 1 case, placebo 1 case) and the desire to defecate following insertion (Proctosedyl 1 case).
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