WOQ-19 improves satisfaction of patients with Parkinson's disease

WCN 2013 No: 1055 Topic: 2—Movement Disorders Freezing of gait in patients with Parkinson disease is a kind of kinetic subcortical apraxia N. Skripkina, O. Levin, T. Makotrova, V. Datieva. Neurology, Russian Medical Academy of Postgraduate Education, Moscow, Russia Background: Freezing of gait is one of the late signs associated with apractic features which may be considered as a subcortical kinetic apraxia. Objective: To investigate the correlation between the frequency and severity of freezing of gait and apractic disorders. Material and methods: We examined 70 patients with PD: 39 men and 31 women (mean age—64.5 ± 8.5 years; mean disease duration —5.1 ± 3.5 years, Hoehn–Yahr stages from 2 to 4, mean UPDRS (part III) score—43.2 ± 11.6). The Gait and Balance examination was carried out with GABS (Jankovic et al., 2001) and FOG-Q (Gurevich et al., 2003) in combination with a comprehensive neuropsychological study including a 72-item apraxia scale. The apraxia scale consists of the oral, arm, leg and trunk apraxia examinations tests, and each of them includes imitation tests and tests on command. Patients were divided into 3 groups according to their FOG-Q score. Results: Freezing of gait was found in 24 (34.3%) of the PD patients. Patients with freezing had advanced stages of PD, a higher UPDRS score and more severe axial symptoms (p b 0.0001) compared with the nonfreezing patients. Patients with a higher FOG-Q score performed worse in the executive and visuospatial cognitive tests and they had a higher leg apraxia score (p b 0.05). Their performance in the apractic tests on command was worse than in the imitation tests. Conclusion: Pathophysiology of FOG in PD is unclear but a subcortical apractic defect should be considered among the possible mechanisms of its origin. doi:10.1016/j.jns.2013.07.433 Abstract—WCN 2013 No: 1058 Topic: 2—Movement Disorders WOQ-19 improves satisfaction of patients with Parkinson's diseaseWCN 2013 No: 1058 Topic: 2—Movement Disorders WOQ-19 improves satisfaction of patients with Parkinson's disease K. Kawabe, T. Takazawa, Y. Yanagihashi, Y. Ishikawa, T. Hirayama, K. Murata, O. Kano, K. Ikeda, Y. Iwasaki. Department of Neurology, Toho University Omori Medical Centre, Tokyo, Japan Objective: To analyse whether a 19-itemWearing-Off (WO) Questionnaire (WOQ-19) improves the sense of satisfaction in patients with Parkinson's disease (PD). Background: It is very difficult to comprehend all complaints of PD patients in outpatient practice. TheWO symptom is particularly underrecognized and associated with patient's quality of life and sense of satisfaction.WOQ-19 has 19 simple questions and is designed to detect WO. Methods: This study included PD patients treated with l-dopa. We compared treatment satisfaction using WOQ-19 to that without using it. The sense of satisfaction was measured using a modified questionnaire for patient–physician communication, which is designed by the Office of Pharmaceutical Industry Research and can evaluate patient's factors, physician's factors and the patient–physician relationship. If WO is recognized using WOQ-19, then entacapone treatment is initiated. Results: Seven PD patients enrolled for this study (two males and five females; age range, 54–88 years; mean, 75.1 years). Among them, two patients were administered entacapone on the basis of WOQ-19 results. Treatment satisfaction was improved using WOQ19, particularly for the question ‘satisfaction of the patient-centred approach’. Conclusion: WOQ-19 may improve the sense of satisfaction in PD patients and be useful for patient education. doi:10.1016/j.jns.2013.07.434 Abstract—WCN 2013 No: 1006 Topic: 2—Movement Disorders Circadian blood pressure and heart rate variations in de novo Parkinson diseaseWCN 2013 No: 1006 Topic: 2—Movement Disorders Circadian blood pressure and heart rate variations in de novo Parkinson disease Y.-S. Oh, S.B. Lee, J.-S. Kim, K.-S. Lee. Department of Neurology, The Catholic University of Korea, Seoul, Republic of Korea Background: Altered blood pressure (BP) regulation and heart rate variations are characteristic findings of cardiovascular Dysautonomia in patients with Parkinson's disease (PD). However, these variations had not been adequately investigated. Objective: The aim of this study was to investigate the patterns and characteristics of 24-hour BP variations and heart rate variations in patients with PD. Patients and methods: Case–control comparisons of 142 consecutive newly diagnosed patients with PD and 57 age-matched controls were performed. All cases underwent clinical assessments and 24-hour ambulatory BP monitoring. The associations between BP and heart rate variations and parkinsonian motor symptoms were investigated. Results: There were significant differences in the distribution of nondipping, the percent of nocturnal BP decrease, the standard deviation of heart rate and nocturnal decrease of heart rate between patients with PD and controls. However, these abnormal diurnal BP and heart rate patterns were not associated with parkinsonian motor symptoms and not related to age, gender, or disease duration. Conclusion: In conclusion, this result suggests that non-dipping and decreased nocturnal heart rate may be one of the cardiovascular autonomic dysfunctions in patients with PD, irrespective of age, disease severity, or motor symptom phenotype. doi:10.1016/j.jns.2013.07.435 Abstract—WCN 2013 No: 1027 Topic: 2—Movement Disorders Motor sequence learning and motor adaptation in primary cervical dystoniaWCN 2013 No: 1027 Topic: 2—Movement Disorders Motor sequence learning and motor adaptation in primary cervical dystonia P. Katschnig-Winter, P. Schwingenschuh, M. Davare, A. Sadnicka, R. Schmidt, J.C. Rothwell, K.P. Bhatia, M.J. Edwards. Department of Neurology, Medical University of Graz, Graz, Austria; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK Background: Motor sequence learning and motor adaptation rely on overlapping circuits predominantly involving the basal ganglia and cerebellum. Given the importance of these brain regions to the pathophysiology of primary dystonia, and the previous finding of abnormal motor sequence learning in DYT1 gene carriers, we explored motor sequence learning andmotor adaptation in patientswith primary cervical dystonia. Methods: We recruited 12 patients with cervical dystonia and 11 healthy controls matched for age. Subjects used a joystick to move a cursor froma central starting point to radial targets as fast and accurately as possible. Using this device, we recorded baseline motor performance, motor sequence learning and a visuomotor adaptation task. Abstracts / Journal of the Neurological Sciences 333 (2013) e109–e151 e130