Cytotoxic Activity Against Cancer Cells of Pistacia vera

Pistacia vera fruit, one of the leading products of today's sweet and snack sector, which has been seen in the history of the kingdom, are able to support daily nutritional needs and treatment of many diseases due to the phenolic and flavonoid content in the literature. Especially the studies on colon cancer and breast cancer are remarkable potential antitumoral activity of pistachio examined. The aim of this study is to examine in more detail the P. vera plant, in which we have previously tested the methanol-hexane extracts of the seed and the test and obtained positive results. As well as observing the cytotoxic activities of the plant extracts and active ingredients obtained from different parts on the lung cancer cells. After counting A549 and HUVEC cell lines which replicated in the medium, were added on 96 well plate. Then, different part of plants extract and 2 major active ingredients also added. Then MTT dye was applied and measured spectrophotometrically. P. vera extracts and active ingredients which studied cytotoxic activity research were found to be effective in all cell lines in general. Particularly P. vera 's remaining after the fruit parts, methanol extract which obtained from waste containing leaf and stem parts and PVK-1 active agent showed selective activity on normal cells and cancer cells, therefore we consider that it has a high therapeutic index. We believe that this plant should be imparted to sciences and health sector with further studies.