Clinical study on the changes of plasma N-terminal precursor natriuretic peptide (NT-pro-BNP) and c-reactive protein in patients with hypertensive cerebral hemorrhage

Objective To investigate the clinical significance of the changes in plasma N-terminal precursor natriuretic peptide(NT-pro-BNP ) and c-reactive protein (CRP) in patients with hypertensive cerebral hemorrhage. Methods Total 65 cases of hypertensive cerebral hemorrhage patients were collected in the Department of Critical Care Medicine of our hospital between January 2016 and December 2016 (observation group), and 30 cases of healthy physical examination people were select as control at the same time (control group). Plasma levels of NT-pro-BNP and CRP were compared between observation group and control group. In the observation group, according to the Glasgow coma score (GCS) , the patients were divided into two groups, the GCS score≤8 group, and the GCS score>8 group. According to the prognosis of disease, the patients were divided into survival group and death group. The differences of plasma levels of NT-pro-BNP and CRP between two subgroups were compared. Results The levels of NT-pro-BNP and CRP in the observation group were higher than that in the controll group, [NT-pro-BNP: (823.67±3 095.51)pg/L 、(43.60±51.06)pg/L, CRP: (52.26±52.50)mg/L 、(1.25±2.29)mg/L, P 8 group, [(73.04±56.34)mg/L、(26.45±32.98)mg/L, P 0.05). Conclusions Plasma NT-pro-BNP and CRP levels in patients with hypertensive cerebral hemorrhage were higher than normal healthy people. The CRP level can reflect the severity of the disease. Combination of NT-pro-BNP and CRP levels can be used as indicators of prognosis. Key words: Intracranial hemorrhage; hypertensive; Plasma NT-pro-BNP; C-reactive protein; Prognosis