Core-shell Regeneration Magnetic Molecularly Imprinted Polymers-based SERS for Sibutramine Rapid Detection

Molecularly imprinted polymers (MIPs) have the ability of predesigned specific recognition that can be selected to construct reliable functional materials. Combining the MIPs with magnetic nanoparticles, resulting in magnetic MIPs (MMIPs) which possess both facile manipulation and high selectivity. In this report, MMIPs microspheres are fabricated by coating a layer of MIPs on Fe3O4@Ag for SERS-based sensing of molecular species. The obtained Fe3O4@Ag@MIPs are further applied for simple, rapid, ultra-sensitive and label-free SERS detection of sibutramine (SIB, illegal additives), with a low LOD of 1.0×10-9 M. Moreover, the MMIPs microspheres exhibits ultra-high adsorption efficiency, selectivity, reusability, and good structural stability, which demonstrates the potential application for SERS. Particularly, the proposed approach of MMIPs-SERS can be successfully applied to quick screening of SIB in slimming supplements such as capsule, tea powder, tablet and the content is 6.18, 13.61, 3.09 mg·g-1, respec...