Clinical observation of Xiazhengtongbi capsule on the treatment of diabetic patients with lower extremity vascular lesions

Objective To study the clinical efficacy of Xiazhengtongbi capsule on the treatment of diabetic patients with lower extremity vascular lesions.Methods 120 patients with diabetic lower extremity vascular disease were randomly divided into two groups.The control group would be given pancreatic kininogenase enteric-coated tablet 2 pills,thrice a day.The treatment group would be given Xiazhengtongbi capsule 4 pills,thrice a day.The changes of clinical symptom were observed before and after the treatment.FPG,2 hPG,blood lipid,the ankle-brachial index(ABI) and the hemodynamic indicators of bilateral dorsalis pedis artery(blood vessel diameter,blood flow,blood flow volume) were detected.Results The total effective rate of treatment group was 85.00%,which was better than the control group(65.51%)(P0.05).There was significant difference between before and after treatment on the ABI,blood vessel diameter,blood flow and blood flow volume in two groups(P0.05).However the effect of treatment group is more obvious than that of the control group(P0.05).There was significant difference between before and after treatment on FPG,2 hPG,HbAlc,TC,TG,LDL-C and HDL-C(P0.05),but there was no difference between the two groups(P0.05).Conclusion Xiazhengtongbi capsule can effectively treat diabetic patients with lower extremity vascular lesions by expanding vascular diameter of arteria dorsalis pedis,raising blood flow of arteria dorsalis pedis and increasing ABI.