Piperidine Mediated Synthesis of Hetero Chalcones and 8-Substituted-2, 5-dihydro-2-(2-furanyl)-4-(2-thienyl)-1, 5-benzothiazepines as Antibacterial Agents
2014
The reactions of 5-substituted-2-amino benzenethiols with hetero chalcones 3 have been carried out in dry toluene containing catalytic amount of piperidine, the products, 8-substituted-2,5- dihydro-2-(2-furanyl)-4-(2-thienyl)-1,5-benzo thiazepines 5 and hetero chalcones 3 were synthesized by piperidine mediated condensation of an ethanolic solution of a 1-thiophen-2-yl-ethanone 2 with corresponding furan-2-carbaldehyde 1. The structures have been established on the basis of elemental (C, H, N) analysis, IR, 1 H NMR, Mass spectral data. The compounds 3 and 5 were screened for
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