Gefitinib Blocks Progression of Osteosarcoma Metastasis via Inhibition of Tumor Extravasation from the Pulmonary Vasculature

Background: Pulmonary metastasis is the major cause of mortality in children with osteosarcoma (OS). We have previously shown that treatment with the drug gefitinib is able to block the development of pulmonary metastasis in a murine model of osteosarcoma via inhibition of RIPK2 in pulmonary macrophages. In this study we sought to investigate the mechanism behind gefitinib’s effect on pulmonary metastatic …