The research progresses of phospholipase D-mediated transphosphatidylation.

Transphosphatidylation denotes the process of the head group exchange in glycerophospholipids which is mediated by Phospholipase D(PLD).This is one of an unique characteristics of PLD and has been well studied in the lipid metabolism,lipid signaling and synthesis of phospholipid of plants,animals and microorganisms.In this paper,the current knowledge on transphosphatidylation,mainly focusing on its catalytic mechanism,substrate specificity,and biological function had been concisely reviewed.Moreover,the future development of this issue had also been discussed.