Monocrystal form of faropenem sodium hydrate and preparation method thereof

2014 
The invention provides a monocrystal form of faropenem sodium hydrate. The monocrystal form serves as an orthorhombic system, wherein the crystal axes of the monocrystal are as follows: a is equal to 5.4998(3) angstroms, b is equal to 9.2057(4) angstroms, and c is equal to 32.4371(12) angstroms; the crystal face included angles are as follows: alpha is equal to 90 degrees, beta is equal to 90 degrees, and lambda is equal to 90 degrees. The invention further provides a preparation method of the monocrystal form, which comprises the following steps: adding faropenem sodium to purified water, heating the mixture to 50 DEG C above until the solid is completely dissolved, stopping heating, slowly cooling the solution, and leaving the solution to stand for 48 hours above, separating out solids, and filtering and drying to obtain the product. The faropenem sodium hydrate with the monocrystal form, disclosed by the invention, has a more stable chemical property.
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