Accelerated solvent extraction coupled to high-performance liquid chromatography-tandem mass spectrometry for simultaneous determination of 11 organophosphorus flame retardants in aquatic products.

A new method based on accelerated solvent extraction was developed for the extraction and determination of 11 organophosphorus flame retardants by using a high-performance liquid chromatography-tandem mass spectrometry technique.; Results: After optimization of the extraction temperature (80 °C), the extraction solvent (n-hexane), the flush volume (40%) and the static extraction time (4 min), all 11 organophosphorus flame retardants illustrated good linearities (R > 0.999). The limits of detection of the method ranged from 0.016 to 26.58 µg kg-1 in the different matrices. The recoveries were 90.4-111.2% with relative standard deviations 0.21-5.3% for the various aquatic products.; Conclusion: The proposed method was applied successfully to detect 11 organophosphorus flame retardants in aquatic products, including grass carp, ribbon fish, mud fish, common eel, shrimp and frog. © 2018 Society of Chemical Industry.; © 2018 Society of Chemical Industry.