Гемореологическая активность экстракта левзеи сафлоровидной при стрептозотоцин-индуцированном диабете у крыс

Rats with streptozotocin-induced diabetes have the hemorheological disturbances which appeared in increase of blood viscosity, elevation of erythrocyte aggregation and decrease of red blood cell deformability. In streptozotocin-induced diabetic rats the concentrations of total lipids, phospholipids (phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine) were decreased and contemporary the content of sphingomyelin and lysophospholipids were enhanced. Administration of extract from Rhaponticum carthamoides (150 mg/kg, i.g., during 14 days) contributed to the decrease of blood viscosity, depression of erythrocyte agregation, improve of erythrocyte deformability and increase of blood’s overall oxygen transport capacity in comparison with controls. Streptozotocin-induced diabetic rats, treated with Rhaponticum carthamoides extract showed the elevation of total lipids, restored phospholipids ratio of external monolayer (phosphatidylcholine, sphingomyelin) and internal monolayer (phosphatidylethanolamine, phosphatidylserine) and also diminution of lysophospholipids in erythrocyte membranes. Extract from Rhaponticum carthamoides contributed to reduction of glucose level in blood and prevent of reduction body mass of streptozotocininduced diabetic rats.