Podocyte expression of the CDK-inhibitor p57 during development and disease

ated cell with a limited proliferative capacity. The precise cell experimental glomerular disease is associated with a decrease cycle proteins necessary for establishing podocyte quiescence during development or permitting podocyte cell cycle re-entry in p57, the levels of all three members of the Cip/Kip family in disease states have not been fully defined. Accordingly, we of CDK inhibitors appear to determine the capability of podostudied the role of the cyclin dependent kinase (CDK)-inhibi- cytes to proliferate. tor p57 Kip2