SYNTHESIS AND EVALUATION OF NOVEL THIAZOLIDINEDIONE DERIVATIVES FOR ANTIDIABETIC ACTIVITY

The aim of study was to synthesize a new series of thiazolidinedione ’ s . Thiazolidinedione ’ s or glitziness forms a significant class of drugs which exhibit biolo gical activities ranging from antidiabetic, anti - inflammatory, antibacterial, antifungal, antiviral and anticancer . In the present study reported a systematic synthesis of thiazolidinedione analogues . A new series of 2 , 4 - thiazolidinedione based derivative s have been synthesized by the condensation of various substituted phenoxy benzene amines and 4 ’ - chlorosulphonyl 5 - benzylidene - 2 , 4 - thiazolidinedione . The structure of these compounds were established by IR and 1 H NMR . These new compounds ( F 1 – F 7 ) were ev aluated for their antidiabetic activity on albino rats . Most of the compounds showed significant antidiabetic activity when compared with the standard drug metformin .