Application of clustering intervention in middle-aged and elderly patients with acute myocardial infarction and its effect on microRNA-208b

Objective To study the application of clustering intervention in middle-aged and elderly patients with acute myocardial infarction and the impact on microRNA-208b indicators. Methods 158 patients with acute myocardial infarction who were diagnosed and treated in our hospital from January, 2016 to October, 2017 were selected as observation objects. They were divided into a control group and a study group according to the random number table method, 79 cases for each group. The control group received routine clinical care, and the study group clustering nursing intervention and routine care. The levels of mental health, changes in plasma microRNA-208b, and incidences of adverse cardiac events before and after intervention were compared between the two groups. Results After the intervention, the SAS and SDS scores of the two groups were lower than those before the intervention, and those in the study group was lower than those the control group, with statistical differences (P<0.05). The level of microRNA-208b was lower after than before the intervention in the two groups, and were lower in the study group than in the control group after the intervention [(1.6±0.44) vs. (3.0±1.3)]. The incidence of adverse cardiac events was was lower in the study group than in the control group [8.9% (7/79) vs. 20.3% (16/79), P<0.05]. Conclusions Clustering intervention has significant effect on middle-aged and elderly patients with acute myocardial infarction. It can effectively improve the level of mental health, myocardial ischemia, reperfusion, and prognosis, and reduce the occurrence of adverse cardiac events and the expression level of microRNA-208b indicators. Key words: Clustering intervention; Acute myocardial infarction; MicroRNA-208b marker; Myocardial ischemia