Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition

From the 1School of Allied Health Sciences, Faculty of Health and Life Sciences, De Montfort University, Leicester, LE1 5RR, UK, the 2Molecular Medicine Laboratory, Institute of Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, PO1 2DT, UK, 3Laboratory of Cellular Metabolism, Department of Biochemistry, Nencki Institute of Experimental Biology of the Polish Academy of Sciences, Pasteur Str., 02-093 Warsaw, Poland, the 4PRIMACEN, Cell Imaging Platform of Normandy, Inserm, IBiSA and PISSARO Proteomic Platform, Institute for Research and Innovation in Biomedicine, University of Rouen; 76821 Mont-Saint-Aignan, France.