Cellular metabolite controls oxidative stress resistance.

: Cellular metabolites such as acetylcoenzyme A and nicotinamide adenine dinucleotide control gene transcription via modulating the reader or eraser protein in histone modification. A ketone body, D-β-hydroxybutyrate is an endogenous metabolite which has been reported as a class Ⅰ histone deacetylases(HDACs). In this chapter, a molecular basis of the ketone body in transcriptional control and protection against oxidative stress is reviewed and discussed.