Tu1122 Predictors of “Difficult to Ablate” Barrett's Esophagus Among 244 Patients With Dysplasia or Early Cancer

G A A b st ra ct s (66%) were diagnosed with OSA and 2,597 (34%) did not have OSA. BE was diagnosed in 339 (7%) subjects with OSA and 113 (4%) subjects without OSA (see Figure 1). Baseline grade of dysplasia in BE subjects was: no dysplasia (280, 81%), LGD (39, 11%) and HGD (25, 7%). Baseline characteristics of cases and controls are displayed in Table 1. Subjects with OSA were found to have an increased risk of having a validated BE diagnosis compared to those without OSA : unadjusted OR 1.6 (95% CI 1.3, 1.99, p value < 0.0001). This increased risk persisted after adjustment for age and gender (OR 1.37 95%CI 1.1, 1.7 p= 0.004). Conclusion: Individuals with OSAmay constitute a higher risk subset for the presence of BE. Prospective studies are needed to confirm this association. The mechanistic links between BE and OSA need to be explored. Table 1: Baseline characteristics of BE cases and controls