Hair Growth Promoting Activity of Nothopanax scutellarium Merr. Leaves

Objective: The aims of this study were to know the safety using Hen’s eggs-chorioallantoic membrane (HET-CAM) test method and hair growth promoting activity of the ethyl acetate fraction of Nothopanax scutellarium leaves. Methods: Safety test was measured by scoring and categorizing irritation onHET-CAM. Meanwhile, activity test was conducted by applying the hair tonic of the ethylacetate fraction on the back of the rabbits, and the length of hair was measured in the 1 st , 2 nd and 3 rd week.In the 3 rd week, the hair growth was weighed and hair diameter also was measuredusing scanning electron microscope (SEM). Results: The result showed that 0.2 gram of ethyl acetate fraction of N.scutellarium leaves have mild irritation effect, whereas the formulation contained with 0.5% and 1% of fraction increased hair growth and hair diameter. Conclusion: The ethyl acetate fraction of N. scutellarium have mild irritan effect, and the hair tonic demonstrated hair growth promoting activity. Key words: Hair Tonic, Hair Growth Activity, Nothopanax scutellarium , Safety, HET-CAM.