Experimental study on effect of fluoride on reproductive system of male rats

Objective To study the effects of excessive fluorine on reproductive system of male rats.Methods Sodium fluoride was administered to male rats with drinking water (150 mg/L) for 10 weeks. The sperm count, the rates of sperm mobility and aberration, the levels of biochemical marker enzyme of testis and epididymidis, as well as the levels of gonadal hormone in serum, were examined. And the pathological alterations of testes were observed.Results Contrasted with control rats, the sperm count, the rate of sperm mobility, as well as the levels of serum testosterone (T) and luteinizing hormone (LH), were suppressed by fluoride. While the rate of sperm aberration was elevated. The differences between two groups were significant ( P 0.05). The pathological alterations of testes were observed.Conclusions The long-term exposure to fluorine of high dose could produce toxicity effect on male reproductive system.