Note: Isolated high-voltage thermo-compensated DC power supply for mass spectrometry

The design of a highly stable isolated high voltage power supply is proposed and developed. The power supply is characterized by good temperature stability (<15 ppm/°C) and very low ripple level (<7 ppm) which were reduced by using a sinusoidal voltage in the transformer conversion. We anticipate that the power supplies of this type can find their utility in modern high-resolution mass spectrometers, particularly in time-of-flight and Orbitrap-type instruments providing a high resolution of ∼100 000 FWHM and high accuracy of m/z determination.