BENDAVIA (MTP-131), A NOVEL MITOCHONDRIA-TARGETING PEPTIDE, NORMALIZES EXPRESSION OF CARDIOLIPIN REMODELING GENES AND PROTEINS IN LEFT VENTRICULAR MYOCARDIUM OF DOGS WITH ADVANCED HEART FAILURE

Cardiolipin (CL) is a phospholipid localized to the inner mitochondrial (MITO) membrane, is essential for oxidative phosphorylation (OX-PHOS) and is synthesized by CL synthase 1 (CLS1) and remodeled by Tafazzin1 (TAZ1), monolysocardiolipin acyltransferase- (MLCLAT1) and acyl-CoA:lysocardiolipin