Effect and mechanism of Danhong injection on isolated mesenteric arterial rings in rats

Objective: To study the effect and mechanism of Danhong injection on isolated mesenteric arterial rings in rats.Method: An isolated vascular ring experiment was conduced to determine the changes in tension of vascular rings with a biological signal collection and analytical system.Result: Danhong injection had no impact on the tension of vascular rings.Danhong injection showed a significant vasodilatation effect on treated arteria rings of norepinephrine,and no remarkable impact was made on the effect without endothium.It showed notable effect on blood vessels treated with Ca2+ and no significant impact on those treated with caffeine.It could inhibit NE-induced intracellular calcium from releasing and external calcium from inflowing.No effects of potassium channel blockers on aorta ring tensile force were found.Conclusion: Danhong injection shows significant vasodilation effect,which mainly works through vascular smooth muscle.Its vasodilation effect may be related to inhibitory receptor,voltage-dependent Ca2-release and IP3 receptor-mediated Ca2+-influx.