valuation of in vitro antioxidant activity of 5H- dibenz [b, f] azepine and its analogues

Synthesis of 5H-dibenz[b,f]azepine and its derivs. bearing different functional groups was performed. The compds. thus synthesized were evaluated for their antioxidant activities by following two well established assays: inhibitory activity on human low d. lipoprotein (LDL) oxidn. and lipid peroxidn. activity in an egg liposome model system. Among the compds., (a) and (d) significantly inhibited human LDL oxidn. and liposome peroxidn., whereas compds. (b), (c), (e) and (f) showed less activity. Butylated hydroxy anisole (BHA) and ascorbic acid (AA) were used as ref. antioxidant compds. Comparative studies with the synthesized compds. were also performed. [on SciFinder(R)]