An integrated map of human 6q22.3-q24 including a 3-Mb high-resolution BAC/PAC contig encompassing a QTL for fetal hemoglobin.

Abstract Genetic studies have previously assigned a quantitative trait locus (QTL) for hemoglobin F and F cells to a region of ∼4 Mb between the markers D6S408 and D6S292 on chromosome 6q23. An initial yeast artificial chromosome contig of 13 clones spanning this region was generated. Further linkage analysis of an extended kindred refined the candidate interval to 1–2 cM, and key recombination events now place the QTL within a region of