Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

Y. Pan,Tian Tian,Chang Ook Park,Serena Y. Lofftus,Shenglin Mei,Xing Liu,Chi Luo,J.T. O’Malley,A. Gehad,J. Teague,Sherrie J. Divito,Robert C. Fuhlbrigge,Pere Puigserver,James G. Krueger,Gökhan S. Hotamisligil,Rachael A. Clark,Thomas S. Kupper

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

2017

Y. Pan
Tian Tian
Chang Ook Park
Serena Y. Lofftus
Shenglin Mei
Xing Liu
Chi Luo
J.T. O’Malley
A. Gehad
J. Teague
Sherrie J. Divito
Robert C. Fuhlbrigge
Pere Puigserver
James G. Krueger
Gökhan S. Hotamisligil
Rachael A. Clark
Thomas S. Kupper

FABP4 and FABP5 are important for the maintenance, longevity and function of CD8+ tissue-resident memory T cells, which use oxidative metabolism of exogenous free fatty acids to persist in tissues and to mediate protective immunity.

Keywords:

Immunity
Metabolism
CD8
Oxidative phosphorylation
Immunology
Biology
In vitro
In vivo
Lipid metabolism
Extracellular
Cell biology
Biological pathway
Fatty acid-binding protein

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