The effect of indomethacin and reserpine on renal vascular escape.
1993
Isolated rabbit kidneys were perfused with Krebs-Henseleit solution in an open system designed to allow study of dose-response relationships. The effects of the cyclooxygenase inhibitor indomethacin and of reserpine on (norepinephrine) noradrenaline (NOR)-induced renal vascular escape were studied. Indomethacin (50 mg/Kg) was given two hours prior to surgery followed by continuous infusion (0.33 mg/min), and blocked renal vascular escape in all doses of NOR tested (10 -7 -10 -4 M) by 70-80%
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