COMPARATIVE COMPARATIVE STUDIES OF NOVEL OXADIAZOLE DERIVATIVE HAVING CHIRAL CENTER AND THEIR ANTI-MICROBIAL ACTIVITIESSTUDIES OF NOVEL OXADIAZOLE DERIVATIVE HAVING CHIRAL CENTER AND THEIR ANTI-MICROBIAL ACTIVITIES

Objective: To synthesize a series of (-) S & (+) S oxadiazole derivatives by the reaction of (-) (2 S )-2-amino-2-(2-chlorophenyl) acetohydrazide & (+) (2 S )-2-amino-2-(2-chloro phenyl) acetohydrazide with con. H 2 SO 4 , L(+) Tartaric acid, L(-) Tartaric acid, Hydrazine Hydrate, POCl 3 and Various aromatic acid respectively. Methods: The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1 H NMR, 13 C NMR and mass spectral data and screened for their antibacterial and antifungal activities against different microorganisms by micro dilution method. Gentamycin, Ampicillin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Nystatin, Greseofulvin were used as standard drugs for bacterial and fungus. Results: The newly synthesized compounds indicate that some of them show better antibacterial and antifungal activity than compared to their reference drug. Conclusion: Comparison of 1, 3, 4 oxadiazole having chiral center, characterized and exhibited promising antibacterial and antifungal activity. Keywords : 1, 3, 4-Oxadiazol, Spectroscopic study, Antibacterial activity, Antifungal activity.