Air pollution and ST-elevation myocardial infarction: A case-crossover study of the Belgian STEMI registry 2009–2013

Abstract Background Previous studies have shown that air pollution particulate matter (PM) is associated with an increased risk for myocardial infarction. The effects of air pollution on the risk of ST-elevation myocardial infarction (STEMI), in particular the role of gaseous air pollutants such as NO 2 and O 3 and the susceptibility of specific populations, are still under debate. Methods All patients entered in the Belgian prospective STEMI registry between 2009 and 2013 were included. Based on a validated spatial interpolation model from the Belgian Environment Agency, a national index was used to address the background level of air pollution exposure of Belgian population. A time-stratified and temperature-matched case-crossover analysis of the risk of STEMI was performed. Results A total of 11,428 STEMI patients were included in the study. Each 10μg/m 3 increase in PM10, PM2.5 and NO 2 was associated with an increased odds ratio (ORs) of STEMI of 1.026 (CI 95% : 1.005–1.048), 1.028 (CI 95% : 1.003–1.054) and 1.051 (CI 95% : 1.018–1.084), respectively. No effect of O 3 was found. STEMI was associated with PM10 exposure in patients ≥75y.o. (OR: 1.046, CI 95% : 1.002–1.092) and with NO 2 in patients ≤54y.o. (OR: 1.071, CI 95% : 1.010–1.136). No effect of air pollution on cardiac arrest or in-hospital STEMI mortality was found. Conclusion PM2.5 and NO 2 exposures incrementally increase the risk of STEMI. The risk related to PM appears to be greater in the elderly, while younger patients appear to be more susceptible to NO 2 exposure.