Secondary Pharmacodynamic Studies and In vitro Pharmacological Profiling

Pharmacological investigations during the drug discovery and development process are broadly divided into three distinct categories: primary pharmacodynamic, secondary pharmacodynamic, and safety pharmacological studies. Secondary pharmacodynamic studies form an important aspect of pharmacological investigations during the drug discovery process. This article discusses drivers for secondary pharmacodynamic studies, different strategic approaches to such studies, and the impact of pharmacological profiling on the drug discovery process. Keywords: secondary pharmacodynamics; drug discovery; drug development; pharmacological profiling; medicine–research