Trypsinogen activation and glutathione content are linked to pancreatic injury in models of biliary acute pancreatitis

Conclusion In models of biliary acute pancreatitis, which might resemble the situation in humans, premature activation of trypsinogen inside the pancreas (“autodigestion”) occurs and is correlated with the extent of ductal and parencymal injury. It is accompanied by a critical spending of protease inhibitors and glutathione, compromising important acinar cell defense and maintenance mechanisms.