Abstract 2214: The Aptamer ARC1779 Is A Potent And Specific Inhibitor Of von Willebrand Factor (vWF) Mediated Ex Vivo Platelet Function In ST-elevation (STEMI) and non-ST elevation (NSTEMI) Acute Myocardial Infarction (AMI)

Bernd Jilma,Florian B. Mayr,Alexander O. Spiel,Patricia G. Merlino,Harold N Marsh,Robert G. Schaub,Jim Gilbert

Abstract 2214: The Aptamer ARC1779 Is A Potent And Specific Inhibitor Of von Willebrand Factor (vWF) Mediated Ex Vivo Platelet Function In ST-elevation (STEMI) and non-ST elevation (NSTEMI) Acute Myocardial Infarction (AMI)

2007

Bernd Jilma
Florian B. Mayr
Alexander O. Spiel
Patricia G. Merlino
Harold N Marsh
Robert G. Schaub
Jim Gilbert

Background: ARC1779 is an aptamer which blocks the A1 domain binding of the vWF A1 domain to platelet GPIb receptors that is now in development for the treatment of AMI. vWF is increased in the eld...

Keywords:

Medicine
Von Willebrand factor
Ex vivo
Receptor
ST elevation
Cardiology
Internal medicine
Aptamer
Myocardial infarction
Diabetes mellitus
Platelet

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