Metastatis of Soft Tissue Sarcomas

Although soft-tissue sarcomas account for <1% of all malignancies, they represent a high percentage of cancer-related deaths worldwide [1]. These tumors may arise in virtually any anatomic site, but most originate in an extremity (59%), the trunk (19%), the retroperitoneum (15%), or the head and neck (9%) [2]. Currently, more than 50 histologic types of soft tissue sarcoma have been identified, but the most common are malignant fibrous histiocytoma (28%), leiomyosarcoma (12%), liposarcoma (15%), synovial sarcoma (10%), and malignant peripheral nerve sheath tumors (6%) [3]. Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood.