Pharmaceutical Applications of Inverse Gas Chromatography

Inverse gas chromatography (IGC) represents a unique refinement of a classic chromatographic method has the potential to unlock some of the more difficult to measure physicochemical properties of pharmaceutical materials such as powder surface energies, acid/base/polar functionality of surfaces, diffusion kinetics, solubility parameters, surface heterogeneity and phase transition temperatures/humidities. In IGC the roles of the stationary (solid) and mobile (gas or vapor) phases are inverted from traditional analytical gas chromatography (GC). In IGC, a single gas or vapor (probe molecule) is injected into a column packed with the solid sample under investigation. Instead of an analytical technique, IGC is considered a materials characterization technique.