Activity of the complement system in blood serum of dogs after treatment of acute necrotic pancreatitis with boiled pancreatic juice

: The investigations were conducted on 14 dogs. To assess the blood serum complement system, the erythrocyte lytic rate of a rabbit (RE) and a sheep (SE), the hemolytic capacity of the complement system against rabbit (RH) and sheep (SH) was measured. In acute necrotic pancreatitis, no changes in SE and SH were revealed either in the control and experimental animals. RH was decreased both in the control and experimental animals. Lower RE was found only in the controls untreated with boiled pancreatic juice. It can be suggested that in the controls the decrease in the parameter RE that characterized the activity of the complement system is associated with the emergence of complement inhibitors, which did not take place when the boiled juice was given. Preventing the complement inhibitors from forming, pancreatic juice is likely to be able to diminish the body's endogenous intoxication which is a cause of death in acute necrotic pancreatitis. This may be suggested by the higher survival of the animals and lower relative extent of pancreatic acinar tissue necrosis after boiled pancreatic juice treatment of acute necrotic pancreatitis.