Signal-on bimodal sensing glucose based on enzyme product-etching MnO2 nanosheets for detachment of MoS2 quantum dots

Abstract The sensitive and rapid detection of blood glucose is very important for monitoring and managing diabetes. Herein, a fluorescent/magnetic bimodal sensing strategy is proposed for glucose detection using a multifunction-responsive nanocomposite (MoS2 QDs-MnO2 NS). MoS2 QDs act as fluorescent probes, and MnO2 nanosheets are used as both quenchers and recognizers in this sensing platform. In the presence of glucose-mediated enzyme product (H2O2), MnO2 nanosheet is etched, thus releasing MoS2 QDs and Mn2+ ions, which causes the significantly enhancement of fluorescent and magnetic signals. Furthermore, MoS2 QDs-MnO2 NS-based fluorescent test paper is constructed for H2O2 sensing with the naked eyes. Under optimal conditions, the dual linear ranges of 20-300 µmol/L and 40-250 µmol/L toward glucose detection are obtained for the fluorescent and magnetic mode, respectively. Furthermore, this bimodal assay exhibits good reproducibility and acceptable accuracy in glucose detection of clinical samples, demonstrating great versatility and flexibility of multifunctional probes in glucose detection.