Improved Reactive Oxygen Species Generation by Chiral Co3O4 Supraparticles under Electromagnetic Fields.

The formation and development of venous thromboembolism accounts for considerable morbidity and mortality. One of the most common methods to treat thromboembolism is the use of thrombolytic drugs to activate fibrinolytic protease. The aim of this treatment was to initiate the lysis of fibrin; however, there are many side-effects associated with this form of treatment. Herein, we fabricated chiral Co 3 O 4 supraparticles (SPs) with a g -factor of up to 0.02 at 550 nm and paramagnetic performance applied in the treatment of thromboembolism under an electromagnetic field (MF). In vitro experiments showed that d -SPs degraded blood clot within 8 hours under MF. Compared to l -SPs, d -SPs exhibited much stronger thrombolytic ability and effectively enhanced the survival rate of thrombosis model mice more than 70% in the 25 d of observation. The results of mechanism study showed that under MF, the level of reactive oxygen species (ROS) produced by d -SPs were 1.5 times higher than that of l -SPs, which might be attributed to the chiral-induced spin selectivity effects. This discovery paves an inspired pathway to develop chiral nanomaterials for the efficient treatment of thrombosis under MF.