Preparation of polymeric composition of linezolid and study of its antimicrobial activity in vitro

This study focuses on the development of the polymeric composition of linezolid based on biodegradable polymeric carriers. Polymeric compositions within linezolid were prepared by the simple emulsification method using a series of polymers such as PLGA 50/50, PLGA 75/25, PLGA-COOH 50/50, Eudragit RL, and Eudragit RS. The best characteristics were achieved by a composition obtained by using the polymer PLGA 50/50. The content of linezolid in the composition was 9.4 ± 0.47%, the inclusion efficiency was 50 ± 2.50%, and the particle size was 275 ± 13 nm. A study of antimicrobial activity of the polymer composition was performed by standard methods using cambric tests on Myulton-Hiller medium at a concentration of active ingredient 500 μg/mL. Experimental results demonstrated that the polymeric composition exhibited higher specific activity against Staphylococcus aureus than the substance.